Melatonin and the aging brain

Melatonin, Neurogenesis, and Aging Brain

Aging is an irreversible process affecting all living organisms. During aging, all organs and tissues of the body reduce their functional capabilities, leading to a progressive loss of physical and cognitive performances. The loss of cells with age is directly related to apoptosis, a mechanism of cell death linked to mitochondrial failure. Attempting to understand the aging process, several the...

Melatonin and human skin aging

Like the whole organism, skin follows the process of aging during life-time. Additional to internal factors, several environmental factors, such as solar radiation, considerably contribute to this process. While fundamental mechanisms regarding skin aging are known, new aspects of anti-aging agents such as melatonin are introduced. Melatonin is a hormone produced in the glandula pinealis that f...

How Melatonin Combats Aging

The Role of Mitochondria in Brain Aging and the Effects of Melatonin

Melatonin is an endogenous indoleamine present in different tissues, cellular compartments and organelles including mitochondria. When melatonin is administered orally, it is readily available to the brain where it counteracts different processes that occur during aging and age-related neurodegenerative disorders. These aging processes include oxidative stress and oxidative damage, chronic and ...

Melatonin and aging: prospects for human treatment.

Human life span, with or without modern medicine is around 85-95 years. All living creatures have their inner clock that measures their daily (circadian) and their seasonal (circannual) time. These time changes are mediated by the alteration of levels of melatonin, an evolutionary ancient hormone, which is produced in many body tissues, including the pineal gland, retina and the gastrointestina...